| abstract |
The present invention relates to novel macrocyclic compounds and salts thereof that bind to serine protease enzymes and / or are inhibitors thereof. The invention also relates to intermediates of these compounds, pharmaceutical compositions containing these compounds, and methods of using the compounds. These compounds are in a range of hyperproliferative disorders, in particular those disorders characterized by tumor metastasis, inflammatory disorders, skin and tissue disorders, cardiovascular disorders, respiratory disorders and viral infections. It is useful as a therapeutic agent for the treatment and prevention of indications. [Selection] Figure 1 |