| abstract |
The present invention inhibits TBK1 and / or IKKε and thus certain aminopyrimidine compounds that can be used in treating inflammation, cancer, septic shock and / or primary open angle glaucoma (POAG) About. Inflammation, RA, SLE, diseases associated with abnormal accumulation of cytosolic nucleic acids (including Sjogren's syndrome, Icardi-Gaucher syndrome, SLE subtypes, frostbite lupus and RVCL), systemic sclerosis, myositis (dermatomyositis and Useful for therapies, including polymyositis), psoriasis, COPD, IBD, obesity, insulin resistance, NIDDM, metabolic syndrome and cancer and therapies to treat complications associated with these diseases and disorders For the manufacture of a pharmaceutical product, the use of at least one of the compounds according to formula I is provided. |