| abstract |
A polypeptide that binds to IL-23R, comprising a polypeptide having multimerization, eg, a trimerization domain, and a polypeptide sequence that binds IL-23R. The multimerization domain may be derived from human tetranectin. IL-23R binding polypeptides inhibit IL-23R activation by native IL-23 and can be used as therapeutic agents for various immune related disorders and cancers. Methods for selecting polypeptides and methods for preparing multimeric complexes are described. [Selection figure] None |