http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013505903-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-25 |
| filingDate | 2010-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2013505903-A |
| titleOfInvention | Lysine-specific demethylase-1 inhibitors and uses thereof |
| abstract | The present invention provides compounds of formula I: (A ′) x- (A)-(B)-(Z)-(L)-(D) wherein: (A) is heteroaryl or aryl; (A ′) is each present If independently selected from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy and cyano, wherein (A ′) is halo, haloalkyl, Substituted with 0, 1, 2 or 3 substituents independently selected from aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, amide and sulfinyl; x is 0, 1, 2 or 3 Yes; (B) is a cyclopropyl ring, where (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is —NH— ; (L) are -CH 2 CH 2 -, - CH 2 CH 2 CH 2 - and -CH 2 CH 2 CH 2 CH 2 - than the selected; (D) is -N (-R1) -R2, -O -R3 and -S-R3, wherein: R1 and R2 are linked together to form a heterocyclic ring with the nitrogen atom to which R1 and R2 are attached, wherein the heterocyclic ring Formula ring is —NH 2 , —NH (C 1 -C 6 alkyl), —N (C 1 -C 6 alkyl) (C 1 -C 6 alkyl), alkyl, halo, cyano, alkoxy, haloalkyl and haloalkoxy Have 0, 1, 2, or 3 independently selected substituents or R1 and R2 are independently selected from -H, alkyl, cycloalkyl, haloalkyl and heterocyclyl, wherein R1 and R2 The sum of the substituents on 2 is 0, 1, 2 or 3 and the substituents are —NH 2 , —NH (C 1 -C 6 alkyl), —N (C 1 -C 6 alkyl) (C 1 -C 6 alkyl) and independently are selected from fluoro; and R3 is -H, alkyl is selected from cycloalkyl, haloalkyl and heterocyclyl, wherein R3 is -NH 2, -NH (C 1 -C 6 alkyl) , -N (C 1 -C 6 alkyl) (C 1 -C 6 alkyl) and independent from fluoro having 0, 1, 2 or 3 substituents selected; compound or an enantiomer represented by, Diastereomers or mixtures thereof, or pharmaceutically acceptable salts or solvates thereof The compounds of the present invention exhibit inhibitory LSD1 activity and are useful in the treatment or prevention of diseases such as cancer. It is. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017513842-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11034991-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019512546-A |
| priorityDate | 2009-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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