| abstract |
A method for detecting, diagnosing, and monitoring thyroid cancer in a subject is described. These methods include a step of measuring a marker containing Ep-ICD and β-catenin in a sample derived from a subject. The invention also provides kits and compositions for carrying out the methods of the invention. The marker of the present invention is a marker for thyroid cancer, specifically, EpCAM polypeptide and its domain (specifically, ectodomain EpEx and intracellular domain EP-ICD), and β-catenin (in the present specification) Collectively referred to herein as “polypeptide thyroid cancer markers”, and polynucleotides encoding such polypeptides and domains thereof (collectively referred to herein as “polynucleotide thyroid cancer markers”) It constitutes a biomarker for cancer (specifically, invasive thyroid cancer, more specifically, undifferentiated thyroid cancer (ATC)). |