| abstract |
In one aspect, the present invention makes compounds with O-benzylnicotinamide analogs, derivatives thereof, and related compounds that are useful as positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5). And a pharmaceutical composition comprising the compound, and a method of using the compound and composition to treat neurological and psychiatric disorders associated with glutamate dysfunction. [Selection] Figure 1 |