http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013504301-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1271 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56938 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-31 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-31 |
| filingDate | 2010-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2013504301-A |
| titleOfInvention | Recombinant alpha hemolysin polypeptide of Staphylococcus aureus with heterologous sequences deleted and inserted in the stem domain |
| abstract | The present invention is a Staphylococcus aureus recombinant single-chain alpha hemolysin polypeptide having a deletion in the stem domain to eliminate hemolytic activity, wherein at least one heterologous sequence is SEQ ID NO: With respect to the wild-type sequence of 1, amino acids 108-151, amino acids 1-5, amino acids 288-293, amino acids 43-48, amino acids 235- Inserted in a region selected from the group consisting of the region defined by position 240, amino acids 92-97, amino acids 31-36, amino acids 156-161, When the heterologous sequence contains 5 or more consecutive histidine residues, the portion of the heterologous sequence other than the portion represented by the 5 or more consecutive histidine residues has a minimum length of 11 amino acid residues. A modified single chain alpha hemolysin polypeptide; or a variant thereof Wherein in addition to the deletion in the stem domain and the insertion of the heterologous sequence, 1 to 50 amino acid residues are added, substituted or deleted with respect to the wild type sequence of SEQ ID NO: 1, and the oligomer And has the activity of binding to a lipid bilayer or cell membrane. The present invention also provides a drug or vaccine comprising the recombinant polypeptide. [Selection] Figure 2 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021035950-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017511312-A |
| priorityDate | 2009-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 228.