| abstract |
The present invention provides a compound of formula (I) or a salt thereof as described herein. The present invention also includes pharmaceutical compositions comprising a compound of formula (I), methods for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I, and formula (I) The compounds are used to provide therapeutic methods for suppressing immune responses or for treating cancer or hematological malignancies. The invention also provides a method of treating a disease or condition (eg, cancer, hematologic malignancy or other malignancy) associated with pathological JAK activation in a mammal (eg, a human) comprising the formula I A method is provided comprising administering to a mammal a compound or a pharmaceutically acceptable salt thereof. |