| abstract |
The present invention relates to a polypeptide having the amino acid sequence set forth in SEQ ID NO: 1 and fragments or derivatives thereof. The invention further relates to a fusion protein comprising the polypeptide and an additional peptide stretch fused to the polypeptide at the N-terminus or C-terminus. Furthermore, the present invention relates to a nucleic acid molecule encoding the polypeptide or fusion protein, a vector comprising the nucleic acid molecule, and a host cell comprising either the nucleic acid molecule or the vector. In addition, the present invention provides for use as a pharmaceutical agent, especially for use in the treatment or prevention of gram-negative bacterial infections, for use as a diagnostic tool, for use as a cosmetic substance, or Relevant to the polypeptide or fusion protein for use as a disinfectant. The invention also provides for the treatment or prevention of gram-negative bacterial contamination of foodstuffs, food processing equipment, food processing equipment, food contact surfaces, medical devices, hospital and operating room surfaces. Related to the use of polypeptides or fusion proteins. Furthermore, the invention relates to pharmaceutical compositions comprising a polypeptide or a fusion protein. |