abstract |
A pyrimidone derivative represented by the general formula (I) or a pharmaceutically acceptable salt thereof used for preventive and / or therapeutic treatment of diseases caused by increased tau protein kinase 1 activity such as neurodegenerative diseases (e.g. Alzheimer's disease) Acceptable salt. [Chemical 1] Wherein, X represents a hydrogen atom, Y represents a hydroxyl group, or X represents a fluorine atom, Y represents a hydrogen atom, R 1 represents a C 1 ~ 6 alkyl group, R 2 is substituted Represents an optionally morpholin-4-yl group, etc.]. |