| abstract |
The present application is formed by a composition comprising hyaluronic acid modified to low levels with functional groups, controlled reaction of such lightly modified hyaluronic acid with a suitable difunctional or polyfunctional crosslinker. And hydrogel precursor compositions and hydrogels derived therefrom. The composition is lightly cross-linked and has low pro-inflammatory properties when injected in vivo and can be used, for example, as a medical device, biomedical adhesive and sealant, Among other things, it can be used for local delivery of bioactive agents. |