| abstract |
A novel method for the production of PEG conjugates of pharmaceutically active compounds is provided. In one or more embodiments of the invention, a method of synthesizing a complex of pharmaceutically active compounds is provided, the method comprising one or more synthetically available intermediate compounds. Attaching at least one water-soluble oligomer directly or via a linker group at a position and completing the synthetic route to yield a complex of pharmaceutically active compounds. The method of the present invention advantageously provides, inter alia, “denovo” synthesis, wherein the intermediate is covalently linked to the water soluble oligomer and the remainder of the complex is then synthesized from the water soluble oligomer intermediate. [Selection figure] None |