| abstract |
Disclosed is a composition comprising micronized purified tanaproget and one or more prepared tanaproget forms. Tanaproget Form I is purified by recrystallization. Recrystallization can be performed using a solvent or solvent system. Several solvents can be utilized to purify tanaproget Form I and can include ethyl acetate, acetone, or combinations thereof. Desirable solvent / antisolvent systems that are useful include acetone / tetrahydrofuran, acetone / methanol, acetone / toluene, and acetone / water. Desirably, tanaproget Form I is purified by recrystallization from acetone / water. [Selection figure] None |