http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013230150-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2220ef7620ca8961c39b52035dfb451a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0662 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0696 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate | 2013-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a66961a8e3262cb4cdea6808db1e679d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00bc0ac4a63638d7a2ac90287c3ebadc |
| publicationDate | 2013-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2013230150-A |
| titleOfInvention | Method for enhancing induction and generation efficiency of pluripotent stem cells |
| abstract | The present invention relates to a method for increasing the induction and generation efficiency of pluripotent stem cells, reducing transcription factors to maintain high reprogramming efficiency, reducing reprogramming cell mutation accumulation, and enhancing operability of reprogramming technology. Provide a method. A method of improving the quality of induced pluripotent stem cells by increasing the induction efficiency of pluripotent stem cells using Jhdm1a and a stem cell inducing factor. The stem cell inducer is a combination of Oct4 and Klf4, a combination of Oct4, Klf4 and Sox2, a combination of Oct4 and Sox2, and a single Oct4. The method further includes the step of exposing the cells to vitamin C, further improving the induction efficiency of pluripotent stem cells compared to the case where vitamin C is not used. Reducing potential carcinogenicity using relatively few stem cell inducers, at the same time, obtaining high induction efficiency and obtaining induced pluripotent stem cells having high-quality germline transmission ability. [Selection] Figure 3 |
| priorityDate | 2011-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 606.