| abstract |
[PROBLEMS] To provide animal cells, transgenic animals, screening methods using the animals, therapeutic and prophylactic agents selected by the screening methods, and treatments, which are used to show remarkable phenotypic changes even in increased gelatinase expression and inflammation. And providing preventive methods. In an animal cell into which DNA in which an MMP-9 gene and an arbitrary expression regulatory region for expressing the gene are functionally linked is introduced, the MMP-9 gene glycine valine at position 102 from the start codon. The expression regulatory region is any one of K14 promoter, K5 promoter, and K10 promoter. [Selection figure] None |