| abstract |
The present invention provides compounds effective in the treatment of ocular diseases and disorders such as age-related macular degeneration and Stargardt disease. A compound of the following formula (A), or a tautomer, stereoisomer, geometric isomer, or pharmaceutically acceptable solvate, hydrate, salt, N-oxide or prodrug thereof . [Wherein Z represents a bond, —O-alkylene chain, alkylene chain or the like, wherein the alkylene chain may be substituted with a halogen atom, hydroxyl group or the like, and G may be substituted with hydroxyl group or the like. R 3 and R 4 represent a hydrogen atom, an alkyl group, etc., R 11 and R 12 represent a hydrogen atom, an alkyl group, an acyl group, —C (NH) NH 2, etc. R 33 represents a halogen atom, an alkoxy group, an alkyl group or the like, and n represents an integer of 0 to 4. ] [Selection figure] None |