http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013213032-A

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
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filingDate 2013-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb6d6d198d405afec95cf5a3680e6798
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c692d39bfe8c30fac66cc33b50cbeb2
publicationDate 2013-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2013213032-A
titleOfInvention Industrial production method of (2RS) -1-dimethylamino-3- {2- [2- (3-methoxyphenyl) ethyl] phenoxy} propan-2-yl hydrogen succinate hydrochloride
abstract A polymorph of (2RS) -1-dimethylamino-3- {2- [2- (3-methoxyphenyl) ethyl] phenoxy} propan-2-yl hydrogen succinate hydrochloride (type I and type II) To provide a process for the commercial production of a mixture, which has a high content of type II crystals, using recrystallization means on an industrial scale. (2RS) Solvent-type recrystallization processes involving aliphatic monocarboxylic acids and non-solvent-type recrystallization processes that cause solid-state crystal transitions by mechanical or fluid energy bombardment (2RS). ) -1-Dimethylamino-3- {2- [2- (3-methoxyphenyl) ethyl] phenoxy} propan-2-yl A process for producing a polymorphic mixture of hydrogen succinate hydrochloride. Thereby, a product having a high content of type II crystals is provided. [Selection] Figure 5
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