| abstract |
PROBLEM TO BE SOLVED: To provide multiparticulates that provide controlled release of an analgesic oxycodone, and a pharmaceutical composition containing the multiparticulates. (E) oxycodone, (b) a water-insoluble ammonium / methacrylate copolymer, (c) a plasticizer, (d) a lubricant, and (e) a water permeability modifier. ) Multi-particulates that are melt-extruded to provide controlled release, wherein the water permeability modifier is a water-permeable ammonium-methacrylate copolymer, and a pharmaceutical composition containing the multi-particulates. The plasticizer is selected from cetyl alcohol, stearyl alcohol, cetostearyl alcohol, sorbitol, sucrose, high molecular weight polyethylene glycol, dibutyl sebacate, tributyl citrate, triethyl citrate, propylene glycol and low molecular weight polyethylene glycol. Is preferred. The lubricant is preferably selected from glyceryl behenate, talc and silica. [Selection figure] None |