| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8bc6d7e07cca0c16f01bcf4a891790c0 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-155 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-133 |
| filingDate |
2013-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d405968c36b969c0b8cb73b20cb7d1a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b91601939c82621503484c89d03e55b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_815d1849152d05728de2ec260d4a4112
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4df479e79bdeac821ddade1a337b54c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d6afd17464a1c119879c1c50ed01d0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69261360b18e83293f6bdaa0ff1973f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f07094c69f21f486e2f90816b0884dc4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22ced5f886633cc4ac09777031f4fa7f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e79362a5b82176152eb2b72135ac144b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63c8dc48ea956f716c89d736f04c7796
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_452df1643796b67ecf269e9a40613c18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb60bc2af2baceec4f82b55488966484 |
| publicationDate |
2013-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2013189466-A |
| titleOfInvention |
Oral preparation containing metformin and α-glycosidase inhibitor, and method for producing the same |
| abstract |
The present invention provides an oral preparation containing metformin and an α-glycosidase inhibitor that exhibits a uniform mixing degree and dissolution characteristics between preparations, and exhibits an effect equal to or higher than that when administered together as separate drugs. . A primary wet granule prepared by using a mixed solution of metformin and hydroxypropylcellulose with the latter aqueous solution as a binding solution is coated with an α-glycosidase inhibitor and a mixed aqueous solution of hydroxypropylcellulose. An oral formulation comprising a next wet granule is provided. In addition, a mixed powder of metformin and hydroxypropylcellulose is put into a fluidized bed granulator, and a primary wet granule is produced by spraying a hydroxypropylcellulose aqueous solution, and α-glycosidase is added to the primary wet granule by a fluidized bed granulator. Spraying an inhibitor and an aqueous hydroxypropylcellulose mixture to form secondary wet granules. [Selection] Figure 1 |
| priorityDate |
2008-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |