http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013179840-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b958e312aa267aa4fd69d36cceb869d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate | 2012-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29675ff5ac133d2aea094a50e016a553 |
| publicationDate | 2013-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2013179840-A |
| titleOfInvention | Non-human animal with enhanced heart-specific acetylcholine production system |
| abstract | An object of the present invention is to provide a non-human animal having an enhanced heart-specific acetylcholine (ACh) production system. In particular, it is an object of the present invention to provide a heart-specific ACh production system-enhanced non-human animal that specifically produces ACh in cardiomyocytes in adult animals. It is another object of the present invention to provide a method for screening a drug for chronic heart failure using this model animal. A non-human animal that expresses an exogenous choline acetyltransferase (ChAT) under the control of a promoter of a gene that is specifically expressed in cardiomyocytes is produced to enhance the heart-specific ACh production system in adult animals. Evaluate physiological significance. The present invention also relates to a stress screening method using a non-human animal having an enhanced heart-specific ACh production system, cardiomyocytes derived from the non-human animal, or heart tissue. [Selection] Figure 6 |
| priorityDate | 2012-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 467.