| abstract |
A novel compound having glucagon receptor antagonist or inverse agonist activity is provided. A compound of formula I. Treat, prevent, or develop a disease or condition (including type 1 and type 2 diabetes, insulin resistance and hyperglycemia) exhibited by a pharmaceutical composition containing the compound and one or more glucagon receptor antagonists It can be used to delay the time to the occurrence or to reduce the risk of its occurrence or progression. (Wherein L represents optionally substituted phenyl, benzofuran-2-yl, etc., R 44 represents hydrogen, methyl, ethyl, etc., R 45 represents an alkyl group, etc., R 46 represents hydrogen, chlorine, fluorine, etc. Represents.) [Selection figure] None |