| abstract |
The present invention provides a novel process for preparing himbacin analogs that are useful as thrombin receptor antagonists. The present application provides a novel process for preparing compound 11 from compound 1, which provides improved yield and elimination of the need for chiral intermediates. The process of the present invention is based in part on the use of base-promoted dynamic epimerization of chiral nitro centers. In another embodiment, the present invention provides a compound prepared by the process of the present invention. [Selection figure] None |