| abstract |
An antibody that binds to an IL-12p40 binding protein, particularly human interleukin 12 (hIL-12) and / or human IL-23 (hIL-23), particularly a chimeric antibody, a CDR grafted antibody, and a humanized antibody. To do. Preferred antibodies have high affinity for hIL-12 and / or hIL-23, and neutralize hIL-12 and / or hIL-23 activity in vitro and in vivo. This antibody may be a full-length antibody or an antigen-binding portion thereof. The antibody or antibody portion is for example to detect hIL-12 and / or hIL-23 in a human subject having a disorder in which hIL-12 and / or hIL-23 activity is detrimental, and hIL-12 and / or hIL- It is useful for inhibiting 23 activity. [Selection figure] None |