| abstract |
The present invention relates to β-hydroxy and amino substituted carboxylic acids which act as matrix metalloprotease inhibitors, in particular β-hydroxycarboxylic acids which are pure as diastereomers, methods for their synthesis and pharmaceutical compositions containing said compounds. In particular, β-hydroxycarboxylic acid pure as a diastereomer is useful for the treatment of various inflammatory diseases, autoimmune diseases and allergic diseases, for example, asthma, rheumatoid arthritis, COPD using the compound. , Rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorder, pulmonary inflammation, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointima To treat neointimal proliferation, stroke, kidney disease, tumor metastasis, and other inflammatory diseases characterized by overexpression and overactivation of matrix metalloproteinases that are proliferative and result in restenosis and ischemic heart failure Useful. [Selection figure] None |