| abstract |
An isolated monoclonal antibody, particularly a human monoclonal antibody, that specifically binds to PD-L1 with high affinity is provided. A method for preparing an anti-PD-L1 antibody comprising the steps of: (a) a heavy chain variable region antibody sequence comprising a specific CDR3 sequence; and / or a light chain variable region comprising a specific CDR3 sequence Providing an antibody sequence; (b) altering at least one amino acid residue in the heavy chain variable region antibody sequence and / or the light chain variable region antibody sequence to create at least one modified antibody sequence; and (C) expressing the modified antibody sequence as a protein. [Selection] Figure 47 |