| abstract |
PROBLEM TO BE SOLVED: To provide a new nucleic acid molecule which can be produced easily and efficiently and can suppress gene expression. A single-stranded nucleic acid molecule comprising an expression suppressing sequence that suppresses expression of a target gene, comprising a region (X), a linker region (Lx), and a region (Xc), wherein the region (Xc) and the region The linker region (Lx) is connected between the region (Xc), the region (Xc) is complementary to the region (X), and at least of the region (X) and the region (Xc) One of the molecules includes the expression suppression sequence, and the linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, the expression of the target gene can be suppressed. [Selection] Figure 1 |