| abstract |
Methods and compositions for treating various diseases through selective killing of target cells using combinatorial targeting methods. A protoxin fusion protein comprising one or more non-natural, cell-targeting moieties, one selectively modifiable activation domain, and one toxin domain, said modifiable A protoxin fusion protein wherein the activation domain contains a substrate for an exogenous enzyme. The composition wherein at least one non-natural, cell-targeting moiety is a polypeptide. [Selection figure] None |