abstract |
To provide a Purine derivatives as adenosine A 1 receptor agonists and methods of use thereof. The present invention relates to a purine derivative, a composition comprising an effective amount of a purine derivative, and a method for reducing the metabolic rate of an animal, a method for protecting the heart of an animal from myocardial injury during myocardial protection. Or a method of treating or preventing heart disease, neuropathy, ischemia, reperfusion injury, obesity, wasting disease or diabetes, wherein an effective amount of a purine derivative is administered to an animal in need thereof A method comprising: [Selection] Figure 9 |