| abstract |
The present invention provides a method of treating animals, particularly domestic animals and humans, with chemotherapy in combination with administration of a CXCR4 antagonist that enhances the effects of chemotherapy. Antagonists to the interaction between the CXCR4 receptor and its ligands enhance the effectiveness of chemotherapy in patients with myeloid or hematopoietic malignancies. Accordingly, in one aspect, the invention is a method for treating a patient suffering from a blood cancer such as lymphoma, myeloma, leukemia, the method comprising one or more CXCR4 antagonists and one or more chemotherapeutic agents. Administration. The CXCR4 antagonist may be administered before chemotherapy, during chemotherapy, and / or after chemotherapy. [Selection figure] None |