| abstract |
The present invention provides a means for elucidating the mechanism of neuralgia after herpes zoster and promoting the regeneration of damaged nerves. Providing means effective in preventing or treating disorders caused by neuronal cell death associated with postherpetic neuralgia, chronic pain, postherpetic neuralgia, stroke, degenerative diseases, and the like, and with few side effects. A neurite outgrowth promoter comprising as an active ingredient an antibody that recognizes a varicella-zoster virus immediate early protein and cross-reacts with a brain-derived neurotrophic factor; containing the antibody as an active ingredient; A prophylactic or therapeutic agent for neurological diseases; a neurite outgrowth inhibitor that recognizes varicella-zoster virus immediate early protein and contains an inhibitory antibody of brain-derived neurotrophic factor as an active ingredient; A preventive or therapeutic agent for a disease associated with nerve hypersensitivity caused by a condition selected from the group consisting of postherpetic neuralgia, chronic pain, experience-dependent social aversion and stress. [Selection figure] None |