| abstract |
A novel method for treating cholesterol disorders is provided. Compositions and methods for treating disorders of cholesterol and lipid metabolism by administration of anti-PCSK9 antibodies or peptide inhibitors of PCSK9. The present invention also includes, in part, an antibody that specifically binds to PCSK9 or an antigen-binding fragment thereof that inhibits binding between PCSK9 and the LDL receptor (eg, a monoclonal antibody, a polyclonal antibody, or a recombinant antibody). Alternatively, provided is a pharmaceutical composition comprising an EGF-A polypeptide and a pharmaceutically acceptable carrier, optionally with additional chemotherapeutic agents (eg, ezetimibe and / or simvastatin). [Selection figure] None |