abstract |
A chimeric non-human animal having a human hepatocyte population in the body, in which the influence of drug metabolism by cells of the non-human animal is suppressed or eliminated. A non-human animal characterized by being (i) immunodeficient, (ii) suffering from liver damage, and (iii) lacking the function of an endogenous Cyp3a gene And a method for producing a chimeric non-human animal, wherein the drug metabolism system of the non-human animal is deleted or suppressed, and the drug metabolism system using the human hepatocyte is provided. [Selection figure] None |