| abstract |
A diagnostic or therapeutic construct targeted by aminophospholipids for use in tumor intervention. Aminophospholipids such as phosphatidylserine and phosphatidylethanolamine are specific and accessible on the luminal surface of tumor blood vessels, And the surprising discovery that it is a stable marker is disclosed. Accordingly, the present invention provides diagnostic or therapeutic constructs targeted by aminophospholipids for use in tumor intervention. Deliver therapeutic agents (including toxins and clotting factors) specifically to the stably expressed aminophospholipids of tumor blood vessels, thereby causing thrombus, necrosis, In particular, antibody-therapeutic agent conjugates and constructs that bind aminophospholipids, as well as methods of inducing tumor regression, are provided. [Selection figure] None |