| abstract |
Disclosed is a solid internal pharmaceutical composition that maintains the dissolution of ibuprofen even after low-temperature storage, and a method for producing the same. SOLUTION: (A) Ibuprofen, (B) aminoalkyl methacrylate copolymer E, and (C) an excipient are mixed, and the resulting mixture is heated at a heating temperature (X ° C.) and a heating time (Y time). Relationship with Y ≧ 0.0052X 2 -1.114X + 60.57 (However, X is 50 to 100, and Y is a value rounded off to the first decimal place.) Heated at a heating temperature and a heating time, and the resulting heated mixture is pulverized. Method. [Selection] Figure 1 |