| abstract |
To provide a human, especially a mammal, as a model of attention-deficit / hyperactivity disorder, in which the gene of GIT1 (G protein-coupled receptor kinase interacting protein 1), which is a neuronal synaptic protein of the brain, is deleted, and Provided is a new drug screening method capable of inducing recovery by administering a drug that is an ADHD candidate substance using a GIT1 gene-deficient mouse. The present invention relates to molecular biology, cell biology, electrobiology, and animal behavioral analysis of GIT1-deficient mice, and administration of a candidate drug in hyperactivity and frontal lobe that is attention deficit hyperactivity disorder. Observe the theta wave recovery and screen for new drugs that can induce the recovery of attention deficit hyperactivity disorder. [Selection] Figure 8 |