abstract |
Provided are novel semi-synthetic macrolides having antibacterial activity, pharmaceutical compositions containing these compounds, and medical treatment methods. A 6-O-substituted erythromycin ketolide derivative represented by the formula (IV-A): Wherein Rc is hydrogen or a hydroxy protecting group, R is a substituted methyl group, A, B, D and E are hydrogen under conditions where at least two of A, B, D and E are hydrogen. , Optionally substituted C1-C6-alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, hydroxy, C1-C6-alkoxy, Br, Cl, F or I Etc. are selected. ] [Selection figure] None |