abstract |
A genetically homogeneous neurological disease model animal and cell that stably presents a disease state of the nervous system disease, and a more efficient means for developing a therapeutic / preventive drug for the nervous system disease using the model animal or cell Offer. A non-human mammal deficient in DBZ gene expression, as compared to a corresponding wild-type animal, (A) the number of cells in the cerebral cortex is decreased, and / or (b) the growth of neurites is suppressed, and / or (c) the cell migration during cerebral cortex formation is delayed, and / Or (d) An animal characterized in that oligodendrocyte differentiation is suppressed. A DBZ gene-deficient mammal, in which oligodendrocyte differentiation is suppressed. A screening method for a therapeutic / prophylactic agent for a nervous system disease by applying a test substance to the animal or cell, and evaluating an improvement in brain organic changes, oligodendrocyte differentiation, or behavioral abnormality. [Selection figure] None |