| abstract |
PROBLEM TO BE SOLVED: To provide a pharmaceutically useful salt and a novel process for preparing a pharmaceutically useful salt. (5S, 8S) -8-[{(1R) -1- (3,5-bis- (trifluoromethyl) phenyl) -ethoxy} -methyl] -8-phenyl represented by formula I -1) Disclosed are the crystalline hydrochloride and tosylate forms of 7-diazaspiro [4.5] decan-2-one and methods for their preparation. Another aspect of the present invention is represented by diffraction angle (2θ, all values show accuracy of ± 0.2), grating “d” spacing (angstrom), and relative peak intensity (“RI”). (5S, 8S) -8-[{(1R) -1- (3,5-bis- (trifluoromethyl) phenyl) -ethoxy} -methyl], characterized by the X-ray powder diffraction pattern shown in Table I The provision of a crystalline hydrochloride monohydrate form of -8-phenyl-1,7-diazaspiro [4.5] decan-2-one (hydrochloride monohydrate compound of formula II). [Selection figure] None |