| abstract |
Provided are DR5 antibodies and uses thereof. The present invention relates to anti-DR5 antibodies with improved properties, compositions comprising such antibodies, methods and means for making such antibodies, and their therapeutics, particularly in the treatment of cancer. Regarding use. In one aspect, the invention relates to an anti-DR5 antibody, or fragment thereof, comprising at least one mutation in the heavy and / or light chain (SEQ ID NO: 11 and 13, respectively) of full-length antibody 16E2. The antibody or antibody fragment exhibits at least the same affinity for DR5 and / or exhibits at least the same biological activity and / or potency as antibody 16E2. In particular embodiments, the antibody or antibody fragment binds essentially to the same epitope as full-length antibody 16E2. [Selection figure] None |