http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013021957-A

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filingDate 2011-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09b081d3ad55360f9d4a576b557e725a
publicationDate 2013-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2013021957-A
titleOfInvention Secondary metabolite screening method, production method thereof, and culture thereof
abstract The present invention relates to a secondary culture in which a microorganism belonging to actinomycetes and a microorganism containing mycolic acid in a cell surface layer are co-cultured to cause actinomycetes to produce a new secondary metabolite or increase its production amount. A metabolite screening method, a production method thereof, and a culture thereof are provided. [MEANS FOR SOLVING PROBLEMS] A microorganism containing mycolic acid stimulates actinomycetes from outside and activates gene expression of a secondary metabolic biosynthesis gene cluster in response to actinomycetes. The heterologous microorganism-derived secondary metabolic biosynthetic gene cluster is integrated on the chromosome or held in a plasmid, and the produced actinomycetes and mycolic acid are co-cultured to cause the actinomycetes to produce new secondary metabolites. Or increase its production. [Selection] Figure 5
priorityDate 2011-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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