| abstract |
In the present invention, the compound of formula (I) (X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , X 8 , R 1 , R 2 , R 3 is as defined above. ) These compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and are therefore useful in the treatment of ASK1-mediated conditions including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases . The invention also relates to pharmaceutical compositions comprising one or more of the compounds of formula (I), and methods for preparing the compounds of formula (I). |