| abstract |
General inflammation, arthritis, rheumatic disease, osteoarthritis, inflammatory bowel disease, inflammatory eye disease, inflammatory or unstable bladder disorder, inflammatory elemental skin disease, systemic lupus erythematosus (SLE), myasthenia gravis Chronic inflammatory conditions including but not limited to autoimmune diseases such as rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiple sclerosis, Sjogren's syndrome and autoimmune hemolytic anemia, Substituted bicyclic heteroaryls and compositions containing them for the treatment of allergic conditions including all forms of hypersensitivity. The present invention also relates to acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative disease (MPD), chronic myelogenous leukemia (CML), T cell acute lymphoblastic leukemia (T-ALL). ), B cell acute lymphoblastic leukemia (B-ALL), non-Hodgkin lymphoma (NHL), leukemias such as B cell lymphoma, and solid tumors such as breast cancer, but are mediated by p110δ activity It also enables methods for treating cancers that are dependent on, or associated with, p110δ activity. |