| abstract |
The present invention relates to new and old substituted 6-arylaminopyridonesulfonamides and 6-arylaminopyrazinonesulfonamides of the following formula I and pharmaceutically acceptable salts, solvates, polymorphs, esters, The invention relates to tautomers, prodrugs or compositions containing them. The proposed chemicals can be used as MEK inhibitors and are useful in the treatment of inflammatory diseases, cancer, and other hyperproliferative diseases. Going further, the present invention provides methods for the treatment of inflammatory diseases, cancer, and other hyperproliferative diseases in mammals, particularly humans. [Chemical 1] |