| abstract |
The present invention provides a composition comprising hemoglobin, particularly PEGylated hemoglobin. PEGylated hemoglobin molecules can move oxygen or carbon monoxide attached to them to adjacent tissue. Exemplary PEGylated hemoglobin formulations of the present invention are virus inactivated. Various compositions of the present invention comprise deoxygenated hemoglobin that may be conjugated to one or more water soluble polymers. PEGylated hemoglobin includes species where the iron atom of the hemoglobin molecule is not bound to oxygen or any other species, and hemoglobin molecules where species other than oxygen, such as carbon monoxide, is bound to the iron atom. The compositions of the invention are formulated as hypotonic, isotonic or hypertonic solutions of PEGylated hemoglobin. The composition is useful for treating and / or ameliorating diseases, wounds and injuries by providing tissue and / or organ oxygenation. [Selection figure] None |