| abstract |
The present invention is directed to formula (I) wherein A 1 , R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the detailed description of the invention and the claims. Compounds that are selective inhibitors of the cysteine protease cathepsin, in particular the cysteine protease cathepsin S or L, especially in the treatment of diabetes, atherosclerosis, abdominal aortic aneurysm, peripheral arterial disorders or diabetic nephropathy As useful as their preparation. |