| abstract |
The present invention provides a humanized antibody that immunospecifically recognizes human α9 integrin. Some of these antibodies inhibit the biological function of α9 integrin, thereby, for example, cancer such as cancer cell proliferation and metastasis, and, for example, rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma Various related to α9 integrin, including inflammatory diseases such as fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granulation species, inflammatory bowel disease (ulcerative colitis and Crohn's disease), autoimmune disease, etc. Shows therapeutic effect on disorder or disease. [Selection figure] None |