| abstract |
The present invention designs and synthesizes vitamin C stearate derivatives of allylpropionic acid non-steroidal anti-inflammatory drugs such as ibuprofen, ketoprofen, naproxen and their addition salts with pharmaceutically acceptable acids or alkalis. Non-steroidal anti-inflammatory drugs such as ibuprofen are one of the usual antipyretic analgesics. In addition to its anti-inflammatory effect, it has remarkable analgesic and antipyretic effects and very good safety, and is applicable not only to adults but also to elderly people, babies and infants. Converting it to vitamin C stearate derivatives and their addition salts with medicinal acids or alkalis can improve their water solubility, facilitate intravenous administration, shorten the onset time, and improve bioavailability. Improves, reduces its irritation to the gastrointestinal tract, enhances its ability to cross the blood-brain barrier, and is a new type of anti-inflammatory, antipyretic, analgesia, arthritis / menstrual pain / multiple sclerosis / cystic pulmonary fibrosis・ It is used to treat premature infant patent ductus arteriosus, to prevent and treat stroke, ischemic encephalopathy, Alzheimer-type dementia and some cancers. |