| abstract |
Disclosed is a solution formulation comprising a corticosteroid, cyclodextrin, and xanthan gum. The formulation is directed to topical application to the eye, ear, or nose. The corticosteroid component of the present invention can be any pharmaceutically acceptable corticosteroid that is not sufficiently soluble in water to provide a target corticosteroid concentration in the solution composition. Suitable corticosteroids include, but are not limited to, dexamethasone, fluorometholone, prednisolone, loteprednol, and rimexolone. A preferred corticosteroid is dexamethasone in the form of dexamethasone alcohol or dexamethasone acetate. The corticosteroid component comprises about 0.01% to 0.3%, preferably about 0.05% to 0.2%, and most preferably about 0.1%. |