| abstract |
Disclosed is an intrauterine system (1) for use in the treatment of functional uterine bleeding, menorrhagia, dysmenorrhea, endometriosis, uterine fibroids, indeterminate complaints of menopause, osteoporosis, and urogenital atrophy. The system is formed by a frame (16) that defines an interior space (20) for receiving a deposit (22) of a therapeutically effective amount of a biologically active compound. The frame has an open structure that allows access to a substantial portion of the outer surface of the deposit, and the deposit has a rate control structure (26) that controls the rate of release of the compound into the uterus. One or more retaining elements (6) are provided on the frame for retaining the frame in the uterus of the female mammal. |