| abstract |
The present application relates to a general formula (A) that inhibits Btk, wherein the variables: Z * or Q 1 , Q 2 , Y 3 , Y 4 , Y 5 and m are as described herein. Are 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-phenyl-1H-pyrazin-2-one derivatives. The compounds disclosed herein are useful for modulating the activity of Btk and treating diseases associated with excessive Btk activity. The compounds are further useful for treating inflammatory and autoimmune diseases with abnormal B cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing a compound of formula (A) and at least one carrier, diluent or excipient. |